Lignans from Hernandia ovigera

Hernolactone (16) is a new bisbenzyl- y -butyrolactone-type lignan isolated from Hernandia ovigera. Although the syntheses of bisbenzyl- y -butyrolactones have been reported by many groups (ref. 2), its synthesis was carried out according to the known procedure (ref. 35) shown in Chart 6. 

Structure Elucidation and Synthesis of the Lignans from the Seeds of Hernandia ovigera L. 

In conclusion, two kinds of 1-hydroxyphenyltetralin-type lignans, epipodophyllotoxin (12) and podophyllotoxin (11), were obtained from desoxypodophy-llotoxin (3), which is available in large quantities from the seeds of Hernandia ovigera L.. 

Isol. from seed oil of Hernandia ovigera. Lignan of deoxypodophyllotoxin type. 

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