Ligation-Desulfurization in Protein Synthesis

Since its inception, the concept of ligation-desulfurization chemistiy [76,77] at Cys residues has been widely adopted for the synthesis of an enormous variety of peptides and proteins, including targets bearing complex PTMs [20, 21, 28, 78]. The following discussion outlines a number of recent, illustrative examples of the technique for the ligation-based assembly of protein targets. 

Kajihara and coworkers recently reported the total chemical synthesis of two glycoforms of the 166-amino acid human glycosyl-interferon-p, bearing a complex 

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