Ligand pairs, orthogonal

Figure 169. Two views of the molecular structure of Ph2Te(S2COEt)2 highlighting (a) the supramolecular association between centrosymmetrically related pairs, and (b) the orthogonal disposition of the xanthate ligands.

David Corey s team has also employed this approach, termed engineered orthogonal ligand-receptor pairs , in studies of retinoid x receptor to find near drugs . These near drugs are chemical tools used to discern the biology of the retinoid x receptors [23],... 

X-ray Crystallography in the Development of Orthogonal Ligand-Receptor Pairs... 

Fig. 8.1 Schematic diagram showing how a naturally occurring small molecule ligand-protein interaction is changed to create an orthogonal ligand-receptor pair.

Orthogonal ligand-receptor pairs have multiple applications for basic cellular and biochemical research. They also have practical applications that could soon be in use in the pharmaceutical and biotechnology industries. 

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