Ligand-lanthanide interaction

Handl, H. L., Gillies, R. J. Lanthanide-based luminescent assays for ligand-receptor interactions. Life Sci. 2005, 77, 361-671. 

Baaden, M., Berny, F., Madic, C., Schurhammer, R., Wipff, G. 2003. Theoretical studies on lanthanide cation extraction by picolinamides Ligand-cation interactions and interfacial behavior. Solvent Extr. IonExch. 21 (2) 199-220. 

The E-F hand proteins parvalbumin, troponin C, calmodulin, calbindin and onco-modulin have been studied with respect to lanthanide interactions. The crystal structure of parvalbumin [82] consists of six a-helical regions labeled as A-F. One Ca2+ ion is bound in the loop joining C and D helices and the second ion in the loop of E-F. Calcium ion is bound to six protein ligands in the CD site. Ca2+ in the EF site is bound to seven protein ligands and a water molecule. 

Frdchet and coworkers [314] have recently described a similar self-assembly of benzyl ether dendrons, possessing carboxylic acid substituents at their focal points by metal-ligand coordination around a core of trivalent lanthanide metals (e.g., Er+, Eu", or Tb+ ). These self-assembled dendrimers were isolated by using ligand exchange reactions to produce structures derived from metal-ligand ionic interactions as shown in Figure 12. As a consequence,... 

The implication of active lanthanide ion participation in labile ligand-metal interactions is ratho unexpected, considering the thermodynamic stabiUty of complexes formed between ions and polydentate aliphatic amines in acetonitrile (Forsberg, 1973). 

The Wyboume crystal field parameters B (f, f), B (d, d), and Bjj(f, d), which describe the interaction due to the presence of the ligands onto the electrons of the lanthanide center. They are deduced from the ligand field energies and wave functions obtained from Kohn—Sham orbitals of restricted DFT calculations within the average of configuration (AOC) reference by placing evenly n — 1 electrons in the 4f orbitals and one electron in the 5d.33... 

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