Ligand-gated channels diseases

Ligand-gated ion channels Allergy, asthma, epilepsy, gastroesophageal reflux, inflammation, ischemia, learning and memory, migraine, neurodegenerative diseases, stroke... 

Modulation of Ligand-Gated Ion Channels for the Treatment of CNS Diseases... 

The N-methyl-D-aspartate (NMDA) receptor is a ligand-gated ion channel that is present throughout the mammalian CNS and is activated by the excitatory amino acid, glutamate. This receptor plays a fundamental role in a number of physiological processes and may be an avenue for the treatment of such disease states as stroke, Parkinson s disease and neuropathic pain. Agents that block the NMDA channel have been shown to alleviate pain in human clinical trials, however the low therapeutic index over side effects such as loss of motor coordination make such compounds unattractive for chronic therapy. 

Many years before the term channelopathies had been established, muscle diseases were identified to be caused by autoantibodies against ligand- or voltage-gated ion channels. Often, these disorders occur in association with malignancy. For example, many patients with thymoma develop autoantibodies to the nicotinic acetylcholine receptor (nAChR) of the... 

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