Ligand dissociation overview

Recent evidence has shown that BEOV is mostly, if not entirely, dissociated prior to tissue uptake (15). This begs the question how is the ligand important in determining relative therapeutic efficacy Is the intact compound relevant to the purported mechanism of action Proposed models of vanadum metabolism, based primarily on studies of inorganic vanadium conqiounds, assume interconversion between V(V) and V(IV) species in vivo (16,17). Are there distinct changes in this pathway with chelated con lexes These, and other related, questions, will be considered in this overview, with enqihasis on very recent experimental findings. 

---