Ligand citrate synthase

Figure 17.10 Conformational changes in citrate synthase on binding oxaloacetate. The small domain of each subunit of the homodimer is shown in yellow the large domains are shown in blue. (Left) Open form of enzyme alone. (Right) Closed form of the liganded enzyme. [Drawn from SCSC.pdb and 4CTS.pdb.]...

Fig. 13.3. Ligand promoted conformational change in the protein citrate synthase (ICTS, 2CTS). The enzyme is a dimer composed of two identical sub-units. In the stereo-diagram, the spatial arrangement of the protein backbone in one of the sub-units is schematically depicted by a ribbon drawing. On cofactor binding (below, additional molecule with orange surface), extended portions of the backbone are shifted to optimize the ligand/receptor interactions [4]...

Fig. 13.12. Binding of citric acid to the active site of citrate synthase (3CTS, stereo-diagram) the ligand is fixed in a gauche-conformation through seven hydrogen bonds...

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