Liebeskind

I.3.4.2.5. Chiral Enolates of Acyl-Metal Complexes J. S. McCallum and L. S. Liebeskind I.3.4.2.5.I. Chiral Iron-Acyl Complexes... 

Herndon JW, Turner SU, McMullen LA, Matasi JJ, Schnatter WFK (1994) In Liebeskind LS (ed) Advances in metal-organic chemistry, vol 3. JAI, London, p 51... 

A novel approach to 3-substituted indolines and indoles via the anionic cyclization of 2-bromo-lV,lV-diallyanilines has been developed simultaneously by Bailey <96JOC2596> and Liebeskind <96JOC2594>. Thus, treatment of 2-bromo-lV,lV-diallylanilines 78 with 2 equivalents of BuLi at -78 °C leads to the formation of the intermediate 79 which may be trapped with an electrophile to afford 3-substituted indolines 80. Aside from ease of preparation, an additional benefit of the intramolecular carbolithiation of <7-lithio-W,Al-diallyl-anilines is the production of Al-allyl-protected indolines, which are easily deprotected using... 

Kidwell CS, Saver JL, Starkman S, Duckwiler G, Jahan R, Vespa P, Villablanca JP, Liebeskind DS, Gobin YP, Vinuela F, Alger JR. Late secondary ischemic injury in patients receiving intraarterial thrombolysis. Ann Neurol 2002 52 698-703. 

Kidwell CS, Liebeskind DS, Starkman S, Saver JL. Trends in acute ischemic stroke trials through the 20th century. Stroke 2001 32 1349-1359. 

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