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Penbutolol Lidocaine

Penbutolol has been shown to increase the volume of distribution of lidocaine in normal patients, implying that it may increase the loading dose requirements in some patients. Clinical signs of overdose may include bradycardia, bronchospasm, heart failure, and severe hypotension. [Pg.553]

The plasma levels of lidocaine after intravenous, and possibly oral, use can be increased by propranolol. Isolated cases of toxicity attributed to this interaction have been reported. Nadolol and penbutolol possibly interact similarly, but there is uncertainty about metoprolol. Atenolol and pindolol appear not to interact. [Pg.263]

In 7 healthy subjects, penbutolol 60 mg daily significantly increased the volume of distribution of a single 100-mg intravenous dose of lidocaine, thus prolonging its elimination half-life. However, the reduction in clearance of lidocaine did not reach significance. ... [Pg.263]

Ochs HR, Skanderra D, Abemethy DR, Greenblatt DJ. Effect of penbutolol on lidocaine kinetics. Arzneimittelforschung (1983) 33,1680-1. [Pg.263]

See other pages where Penbutolol Lidocaine is mentioned: [Pg.124]    [Pg.137]    [Pg.142]    [Pg.160]    [Pg.228]    [Pg.345]    [Pg.384]    [Pg.415]    [Pg.460]    [Pg.519]    [Pg.590]    [Pg.622]    [Pg.659]    [Pg.745]    [Pg.801]    [Pg.845]    [Pg.888]    [Pg.906]    [Pg.933]    [Pg.958]    [Pg.979]    [Pg.1002]    [Pg.1025]    [Pg.1047]    [Pg.1142]    [Pg.1183]    [Pg.1205]    [Pg.1210]    [Pg.1221]    [Pg.1313]    [Pg.1366]    [Pg.1380]    [Pg.1426]    [Pg.1450]    [Pg.1463]    [Pg.1467]    [Pg.263]    [Pg.82]    [Pg.124]    [Pg.137]    [Pg.142]    [Pg.160]    [Pg.228]    [Pg.384]    [Pg.415]    [Pg.460]    [Pg.519]   
See also in sourсe #XX -- [ Pg.263 ]



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Lidocaine

Penbutolol

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