Lidocaine inhalational

Several other therapeutic effects of sodium channel blockers have been suggested. Most of these stem from clinical activities of approved anticonvulsants and antiarrhythmics with sodium channel blocking activity. Beneficial effects of sodium channel blockers for the treatment of bipolar disease are suggested by clinical data with lamotrigine [63-67], phenytoin [68], topiramate [69], and carbamazepine [70,71]. In addition, clinical studies with lidocaine suggest efficacy in the treatment of tinnitus [72] and, as an inhaled formulation, in the suppression of cough [73,74]. 

Chen CY, Bonham AC, Plopper CG, Joad JP (2003) Neuroplasticity in nucleus tractus sohtarius neurons after episodic ozone exposure in infant primates. J Appl Physiol 94 819-827 Chong CF, Chen CC, Ma HP, Wu YC, Chen YC, Wang TL (2005) Comparison of lidocaine and bronchodilator inhalation treatments for cough suppression in patients with chronic obstructive pulmonary disease, Emerg Med J 22 429 32... 

The dosage of propofol may need to be reduced after the use of bupivacaine or lidocaine (e.g. during regional anaesthetic techniques). Similarly, epidural lidocaine reduces sevoflurane requirements, and is likely to have the same effect on other inhalational anaesthetics. 

A randomised, double-blind, placebo-controlled study involving 44 patients found that lidocaine epidural anaesthesia (15 mL of 2% plain lidocaine) reduced the MAC of sevoflurane required for general anaesthesia by approximately 50% (from 1.18 to 0.52%). This implies that a lower dose of inhalational anaesthetic provides adequate anaesthesia during combined epidural-general anaesthesia than for general anaesthesia alone. ... 

Respiratory Intravenous lidocaine is commonly used as part of anesthetic induction, especially in children, to prevent reflex bronchoconstriction caused by endotracheal intubation. Intravenous lidocaine significantly improves intubating conditions when it is used as part of inhalational induction. However, intravenous lidocaine can cause reduced airway diameter in... 

In many cases, no sedation is required except that provided by sterile Xylocaine (lidocaine) jelly that lubricates the catheter in boys. A quick examination performed by an experienced radiologist should not be painful. Postprocedural minor discomfort can occur, and it seems less worrisome when announced. Improvement by hydration and local care is the rule. In some children, major anxiety can be present. Inhalation of an equimolecular mixture of nitrous oxide and oxygen (Entonox) in fasting children can be helpful (Schmit and Sfez 1997). In uncooperative children who are too young to breathe gas, rectal midazolam can occasionally be used (Hypnovel 0.3 mg/kg, maximal dose 5 mg). For safety, sedation procedures should preferably be organized in collaboration with the department of anesthesiology. 

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