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Cosmid libraries

Metagenomics has been applied to the search for novel genes encoding the synthesis of vitamins such as biotin and vitamin C [47,76]. Seven cosmids were detected in metagenomic libraries obtained after avidin enrichment of environmental samples. The highest levels of biotin production in this study were detected in a cosmid... [Pg.77]

We thank K. Welzel (Combinature Biopharm, AG, Berlin, Germany) for the constrnction and screening of the genomic cosmid libraries. We are grateful to all former and present members of onr group who contributed to this work. [Pg.109]

Small peptides have also been obtained. Thus, the construction of a cosmid library in Escherichia coli, and cloning and heterogously expressing individual biosynthetic pathways, led to the discovery... [Pg.207]

Tab. 4.1. Average insert sizes of plasmid-, cosmid- or BAC-based environmental libraries. Tab. 4.1. Average insert sizes of plasmid-, cosmid- or BAC-based environmental libraries.

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Cosmids

Cosmids genomic library construction

Environmental libraries cosmid library

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