Library aminoketone

FIGURE 7.17 Model library of 6 aminoketones obtained by Moffatt oxidation. 

An application of artificially imparted molecular recognition [79] is shown in Figure 13. A small model library (six discretes) of aminoketones was obtained by Moffatt oxidation of hydroxyethylamines using dichloroacetic acid in DMSO and the tertiary amine-tagged EDC as a carbodiimide. After 24 h at room temperature, the sulfonic acid resin 3 and the tertiary amine resin 2 were added, the mixtures were stirred for 20 h, and the resulting solutions contained the pure library components (yields from 48% to 91%, HPLC purities around 90%) with no diimide or urea or dichloroacetic acid left. While resin 2 acted as a molecu-... 

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