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Libraries chemotype-focused

Picked and purchased compounds, as well as all new designed chemotype focused libraries, were assessed in terms of quality, diversity, and drug-likeness [58], The... [Pg.236]

Application of this topological framework analysis to ion channel modulators yields access to privileged ion channel chemotypes. Conversion of these frameworks into appropriate scaffolds for synthesis allows subsequent building of ion channel focused libraries. [Pg.234]

However, identification of ion channel modulators by screening compound libraries enriched with ion channel privileged chemotypes offers rapid, efficient access to lead compounds. Flexible data-driven building and optimization of such an ion channel focused library will enable better and faster lead identification of ion channel modulators. [Pg.239]

See other pages where Libraries chemotype-focused is mentioned: [Pg.69]    [Pg.179]    [Pg.306]    [Pg.17]    [Pg.36]    [Pg.128]    [Pg.151]    [Pg.144]    [Pg.237]    [Pg.238]    [Pg.238]    [Pg.9]    [Pg.10]    [Pg.101]    [Pg.760]    [Pg.838]    [Pg.966]    [Pg.1]    [Pg.159]    [Pg.397]    [Pg.146]    [Pg.146]    [Pg.21]    [Pg.38]   
See also in sourсe #XX -- [ Pg.236 ]



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