Lewis acid-base interactions systematics

Sinicki and Berg varied the Lewis acid-base interactions systematically and found a correlation between adhesion measured by peel testing and the calculated thermodynamic work of adhesion [118]. 

The topic of interactions between Lewis acids and bases could benefit from systematic ab initio quantum chemical calculations of gas phase (two molecule) studies, for which there is a substantial body of experimental data available for comparison. Similar computations could be carried out in the presence of a dielectric medium. In addition, assemblages of molecules, for example a test acid in the presence of many solvent molecules, could be carried out with semiempirical quantum mechanics using, for example, a commercial package. This type of neutral molecule interaction study could then be enlarged in scope to determine the effects of ion-molecule interactions by way of quantum mechanical computations in a dielectric medium in solutions of low ionic strength. This approach could bring considerable order and a more convincing picture of Lewis acid base theory than the mixed spectroscopic (molecular) parameters in interactive media and the purely macroscopic (thermodynamic and kinetic) parameters in different and varied media or perturbation theory applied to the semiempirical molecular orbital or valence bond approach [11 and references therein]. 

The rational design of chelating agents as antidotes requires a careful consideration of acid-base chemistry. Metal ions are Lewis acids, while the chelating agents or ligands are Lewis bases. The concepts of hardness and softness may be used to describe systematically the interaction between them. A hard metal cation is one that retains its... 

Acid-base characterizations of metal oxide surfaces are often used to explain their catalytic behavior. Extensive studies have been performed on the interaction of acid-base probe molecules with powders or supported metal oxides. The adsorption of NH3 at cation sites has been used to characterize the Lewis acidity of metal oxides. The systematic use of CO adsorption at room temperature as a probe for... 

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