Levothyroxine Nelfinavir

THYROID HORMONES ANTIVIRALS - PROTEASE INHIBITORS 1 efficacy of levothyroxine by ritonavir (with or without lopinavir) and possibly indinavir and nelfinavir Uncertain possibly T metabolism via induction of glucuronosyl transferases Monitor thyroid function closely... 

A man needed to have his levothyroxine dosage doubled when he took ritonavir/saquinavir, and another woman possibly had a similar reaction when given indinavir then nelfinavir. Conversely, another woman needed a markedly reduced dose of levothyroxine when given indinavir. 

Conversely, in another woman a 4-week course of antiretroviral prophylaxis, including 2 weeks of indinavir then 2 weeks of nelfinavir, tended to reduce the efficacy of levothyroxine 125 micrograms daily. She was fatigued and had elevated TSH and hypercholesterolaemia, which resolved after the antiretroviral therapy was stopped. ... 

---