Levodopa/carbidopa liquid formulation

The controlled-release (CR) formulation is more slowly absorbed and longer acting than immediate-release tablets. Patients need to increase the total daily dose by 30%, as it is not as bioavailable as the immediate-release levodopa/carbidopa. The CR formulation has a delayed onset (45 to 60 minutes) compared to the standard formulation (15 to 30 minutes). Thus, patients may also need to take immediate-release tablets or even a liquid formulation when they want a quicker onset of effect, such as with the first morning dose.1,8,25... [Pg.481]

Patients with severe dyskinesias and off periods may achieve more constant blood concentrations (lower peak and higher trough concentrations) by taking a liquid formulation of levodopa with carbidopa. Each day patients make a 1 mg/mL levodopa... [Pg.481]

Ting, S. Liquid chromatographic determination of levodopa, levodopa-carbidopa, and related impurities in solid dosage forms. J.Assoc.Off.Anal.Chem., 1986, 69, 169-173 [simultaneous carbidopa, levodopa acetaminophen is IS formulations]... [Pg.24]

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