Leuprolide acetate plasma concentrations

Figure 8 (A) In vitro permeability of candidate drug molecules in the presence of synergistic combinations of penetration enhancers (SCOPE) formulations. Open circles indicate passive skin permeability and closed circles indicate skin permeability in the presence of SCOPE formulations as a function of the molecular weight of the solute. (B) In vivo delivery of leuprolide acetate, a synthetic analogue of LHRH in hairless rat model, y-axis shows blood plasma concentration of leuprolide acetate as a function of time for control formulation (open circles) and SCOPE formulation (closed circles). Abbreviation-. LHRH, luteinizing hormone-releasing hormone.

Figure 9.4 Plasma concentrations of leuprolide acetate (C eupro) following single oral administration of leuprolide saline solution and microemulsion at a dose of 3 mg kg-1 in rats (n = 5 mean SD) as a function of the time after administration (tadmm). The leuprolide acetate microemulsion was superior to that of saline solution. (Figure redrawn with data from Ref. [1 06], reprinted with permission of Elsevier.)...

Fig. 6 Plasma levels of leuprolide and luteinizing hormone following iontophoteric administration of leuprolide to healthy male volunteers, as a function of leuprolide concentration and ionic strength. Ionic strength (M acetate buffer) is shown in parentheses next to leuprolide concentration. (From Ref. ° with permission from the copyright holder.)...

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