Leukocytes and phagocytosis

With long-term treatment, IgG subclass deficiencies can become marked (312). There is suppression of the antigen-antibody reaction, and since this reaction itself normally results in liberation of kinins, the latter is also suppressed. Failure of kinin liberation leads in turn to inhibition of invasion of sensitized leukocytes and reduced production and maturation of phagocytes. Undoubtedly, it is true that using minimal effective doses will avoid the most serious consequences, but the problem cannot be fully circumvented, since the antiinflammatory effects themselves involve some inhibition of the migration of leukocytes and phagocytosis. 

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