Leukocyte glycoprotein deficiency

Anderson DC, Springer TA. Leukocyte adhesion deficiency an inherited defect in the Mac-1, LFA-1, and P150 glycoproteins. Annu Rev Med 1987 38 175-194. 

An absence of R-type binding protein has been reported in two adult siblings by Carmel and Herbert (C20). R-Type protein was virtually absent from their leukocytes and saliva, and as was expected they had very low levels of serum vitamin B12. The absence of the protein did not appear to have any adverse effects. Other members of this family have also been found to have an absence of, or very low levels of, R-protein (H26). There was no general deficiency of plasma glycoproteins in these patients and the amounts of thyroid binding globulin, thyroxine, ceruloplasmin, and transferrin were all normal. 

Mice lacking al,3Fuc-TVII are deficient in leukocyte extravasation into areas of inflammation, a phenotype similar to P- and E- selectin deficient mice and to LADII pathology in humans [101]. Unlike neutrophils, carcinoma cells may not express leukocyte cell surface glycoproteins (e.g. PSGL-1), however selectin ligands... 

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