Leukocyte aggregation test

Figure 2. Adhesion to serum-coated glass slides of sheared and unsheared leukocytes was reduced significantly by 1 X 10 6M RA-233 and 3 X 10 6M PGEi ( SEM). Only a less adherent population of cells remained to be tested at shear stresses greater than 300 dyn/cm2 because cell aggregates were removed during processing. Keu , without drug (control) and A,...

If the test chemical or its metabolites are present in the urine at high concentrations, it or they may precipitate from solution and form solid aggregates visible on examination. This may result in irritation or mechanical abrasion, or cause inflammation of the kidney, ureters, or bladder, with findings of erythrocytes, leukocytes, and/or hemoglobin in the urine. 

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