Leuconotis griffithii

In the plant, the unstable dihydrorhazinilam 25 is most certainly the direct biogenetic precursor of rhazinilam, which is an isolation artefact. Indeed, 25 was isolated together with 3 from the Apocynaceae Leuconotis eugenifolia and Leuconotis griffithii [58,59] and Kopsia singapurensis [60]. The question whether (+)-l,2-didehydroaspidospermidine 46 is the actual biogenetic precursor of 25 is still open. 

Gan C-Y, Low YY, Thomas NF, Kam TS. Rhazinilam-leuconolam-leuconoxine alkaloids from Leuconotis griffithii. J Nat Prod 2013 76(5) 957-64. 

Bisleuconothine A (127), consisting of ebuman- and Aspidosperma-type units with a linkage between C-16 and C-12, was isolated from the baik of Leuconotis griffithii (Apocynaceae) (Figure 19). Its structure... 

Leuconotis griffithii (Apocynaceae), together with a new bisindole, leucofoline... 

Bisleucocurine A (144). the first example of a Strychnos—Strychnos bisindole alkaloid with N-1—C-17 and C-12—C-2 double linkages, was isolated from the leaves of Leuconotis griffithii (Apocynaceae), together with... 

Four bisindole alkaloids, leucoridines A—D (146-149), were isolated from the stem bark of Leuconotis griffithii (Apocynaceae)." Leucoridine A (146) was composed of two tubifoHne (150)-like units having a spiro center at C-16, an enamine double bond, and a tetrahydropyridine ring consisting of the atoms C-16, C-22, N-1 C-2, C-16 and C-22 The relative... 

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