Leucine hydrolysis, metal catalysis

Found to be subject to metal ion catalysis, but the discovery by Kroll in 1952 that the hydrolysis af a-amino acid esters was catalyzed by metal ions stimulated considerable interest in the area. Many of these reactions can be considered as simple model systems for such metalloenzymes as arboxypeptidase A, leucine aminopeptidase and glycylglycine dipeptidase.25... 

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