Lemieux-Johnson reagent

This reaction was first reported by Lemieux and Johnson in 1956. It is a conversion of an olefin into two individual aldehydes by means of an oxidative cleavage of a carbon-carbon double bond with osmium tetraoxide-sodium periodate. Therefore, it is known as the Lemieux-Johnson oxidative cleavage, Lemieux-Johnson reaction, or simply Lemieux-Johnson oxidation." In addition, the combination of osmium tetraoxide and sodium periodate is referred to as Lemieux-Johnson reagent. It should be pointed out that a lactol may be obtained directly from the oxidation of the olefin with a hydroxyl group near the oleflnic bond." ... 

Periodate-osmium tetroxide oxidation (Lemieux-Johnson). - The reagent, periodate catalyzed by osmium tetroxide, operates as follows. Osmium tetroxide adds to a double bond to form an osmate ester, and this is oxidized by periodate with cleavage to carbonyl compounds and regeneration of osmium tetroxide. Discovery of the... 

---