Leloir pathway

A somewhat more complicated route into glycolysis is followed by galactose, another simple hexose sugar. The process, called the Leloir pathway after Luis Leloir, its discoverer, begins with phosphorylation from ATP at the C-1 position by galactokinase ... 

Both transferases from the Leloir and non-Leloir pathways have been employed for the in vitro synthesis of oligosaccharides and glycoconjugates. Glycosidases have also been exploited for synthesis. The function of glycosidases in vivo is to cleave glycosidic bonds,... 

Glycosyl transferases are essential enzymes for oligosaccharide biosynthesis. These enzymes can be classified as enzymes of the Leloir pathway and those of the non-Leloir pathway. The glycosyltransferases of the Leloir pathway are involved in the biosynthesis of most iV-linked... 

FIG. 2. Common nucleotide donors for glycosyltransferases of the Leloir pathway. 

A variety of linear oligo- and polysaccharides can be also prepared using glycosyltransferases of the non-Leloir pathway, which utilize sugar z-phosphates as... 

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