Ledderhose syndrome

The incidence of barbiturate-induced Dupuytren s contracture, frozen shoulder, Ledderhose syndrome, Peyronie s disease, fibromas, and joint pains may be up to 10% (6). Most affected patients develop connective tissue changes in the first year, although these become disabling at a later stage. These complications should be recognized early, since they are often reversible (SED-12, 137) (7). 

Recurrent plantar fibromatosis, also known as Ledderhose syndrome, occurred in a patient who had taken phenobarbital for a long time [237 ]. 

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