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Lead selecting target defines

Today, selected targets of interest are transferred to the HTS aiming at discovering a hit , and subsequently a lead structure within one to two months. After that time, the target concerned is replaced by a new one. Thus, rapid characterization and structure elucidation of the active principles of interest from natural sources are critical with reference to competition with synthetic libraries of pure and structurally defined compounds. Elaboration of LC-MS and LC-NMR techniques to accelerate structure elucidation of bioactive principles from natural sources is currently underway. Combination of these techniques with databases comprising a maximum of known natural compounds will probably contribute substantially to more interest in natural products for application in drug discovery. [Pg.143]

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Lead selection

Selective targeting

Selectivity defined

Target selection

Target selectivity

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