Lasso mechanism

Lasso mechanism The groups that are going to react together are placed next to each other and then encircled, i.e. lassoed , to indicate that they have bonded, while the remaining truncated molecules fuse together. A small molecule, typically H20, formed by fusion of the two groups, is... 

This clearly sets limitations to which any mechanism advanced for the reaction will have to conform, and gives the lie to that prime tenet of lasso chemistry groups are eliminated most readily when closest together ... 

By taking into account the experimental observation of the stereochemistry of the product, and assuming that the two reactions proceed by the same mechanistic route, it is apparent that the mechanism cannot proceed along the pathway indicated by the lasso approach. 

Several tools should be checked before the procedure, such as mechanical polypropylene sheaths, stylets, snares (catcher, lassos), and transfemoral workstation. Also, standard implantation equipment can be necessary (introducer sheaths, guide wires, stylets). Please refer to the dedicated chapter of this book for a more complete and exhaustive discussion about these items. 

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