Laser desoiption

Steiner, W.E. Clowers, B.H. English, W. A. Hill, H.H., Atmospheric pressure matrix-assisted laser desoiption/ionization with analysis by ion mobility time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2004, 18, 882-888. 

Colby, S.M. King, T.B. Reilly, J.P. Improving the Resolution of Matrix-Assisted Laser Desoiption/lonization Time-of-Flight Mass Spectrometry by Exploiting the Correlation Between Ion Position and Velocity. Rapid Common. Mass Spectrom. 1994, 8, 865-868. 

Montando, G. Montaudo, M.S. Puglisi, C. Samperi, F. 2-(4-Hydroxyphenyl-azo)benzoic acid a Solid Matrix for Matrix-Assisted Laser Desoiption/Ioniza-tion of Polystyrene Rapid Commun. Mass Spectrom. 1994,8, 1011-1015. 

Martin, R.L. and Brancia, F.L., Analysis of high mass peptides using a novel matrix-assisted laser desoiption/ionisation quadrupole ion trap time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom., 17, 1358-1365 (2003). 

Various workers have discussed the fractionation of polyethylene glycols using laser desoiption / Fourier transform ion cycloUxjn resonance mass spectrometry" and flow field - flow fractionation" techniques. 

Laser Desorption/Ablation Ionization Methods. Matrix-assisted laser desoiption ionization (MALDI) relies on the use of a solid chromophQric matrix, chosen to absorb laser light, which is co-mixed with the analyte (4). Typically, a solution of a few picomoles of analyte is mixed widi a lOO-to-5000 fold excess of the matrix in solution. A few microliters of the resulting solution are deposited on a mass spectrometer solids probe, and the solvent is allowed to evaporate before inserting the probe into the mass spectrometer. When the pulsed laser beam strikes the sample surface in the spectrometer, the sample molecules are desorbedAonized at high efficiency. The various mechanisms for matrix and non-matrix assisted laser desorption have been discussed (5,6). 

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