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Largomycin isolation process

Process Developments in the Isolation of Largomycin F-II, a Chromoprotein Antitumor Antibiotic... [Pg.136]

Prior to attempting any process development work, it was decided to evaluate the process reported by Yamaguchi et at (2) for the isolation of largomycin F-II. [Pg.140]

NCI-FCRF Process II-B (Scheme 5). In this process the freeze-thaw step of mycelia suspension, to liberate largomycin F-II, of NCI-FCRF Process II-A has been replaced by vigorously mixing the mycelia suspension for 1 hour. The results of a 240 gallon fermentation run are summarized in Scheme 5. A comparison of the properties of the isolated product with the standard compound is shown in Table II, and their polyacrylamide gel electrophoresis pattern is shown in Figure 5. [Pg.146]


See other pages where Largomycin isolation process is mentioned: [Pg.39]    [Pg.136]    [Pg.143]    [Pg.143]    [Pg.146]    [Pg.154]   


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