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Large-scale conformational changes

One has no results for this case derived consequently from the basic equations (7.6) with local anisotropy. Instead, to find conformational relaxation equation, we shall use the Doi-Edwards model, which approximate the large-scale conformational changes of the macromolecule due to reptation. The mechanism of relaxation in the Doi-Edwards model was studied thoroughly (Doi and Edwards 1986 Ottinger and Beris 1999), which allows us to write down the simplest equation for the conformational relaxation for the strongly entangled systems... [Pg.145]

Onufriev A, Bashford D, Case DA (2004) Exploring protein native states and large-scale conformational changes with a modified generalized born model. Proteins 55(2) 383-394... [Pg.112]

Large scale conformational changes play an important role in enzyme function several examples are reviewed in this chapter. Molecular mechanics calculations, in particular, energy minimization and normal mode calculations, as well as molecular dynamics simulations have been employed to provide an understanding of the mechanisms of such motions and their role in the enzyme. [Pg.189]

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See also in sourсe #XX -- [ Pg.7 , Pg.67 , Pg.83 ]



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Conformation change

Conformational changes

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