Lansoprazole Paracetamol

Lansoprazole modestly increased the rate, but not the extent, of absorption of paracetamoi soiution. Omeprazoie does not appear to have any effect on the metaboiism of phenacetin or paracetamol. 

In a study in 6 healthy subjects, lansoprazole 30 mg once daily for 3 days increased the peak level of paracetamol (given as a single 1-g dose in solution) by 43%, and decreased the time to peak paracetamol levels by half (from about 35 to 17.5 minutes). However, lansoprazole had no effect on the AUC and elimination half-life of paracetamol. ... 

The findings from these studies suggest that neither lansoprazole nor omeprazole cause any clinically important changes in the pharmacokinetics of paracetamol. No special precautions appear to be needed on concurrent... 

Imatinib increases serum tacrolimus levels and is therefore predicted to increase ciclosporin levels. Imatinib may also increases the levels of some benzodiazepines (e.g. midazolam), some calcium-channel blockers (e.g. nifedipine), oestrogens, paracetamol, pimozide, and warfarin. In one case lansoprazole was suspected to have raised imatinib levels. 

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