Lactones tandem cross-metathesis/hydrogenation

Cossy et al. demonstrated that, in the presence of the ruthenium catalyst 10 and Pt02, the tandem cross-metathesis—hydrogenation—cyclization reactions of the alkenol 19 with acrylic acid 20 or acrolein 21 under H2 atmosphere gave the lactone 22 or lactol 23, respectively (Scheme 8).89 The ruthenium catalyst 10 and Pt02 are compatible under the reaction conditions. 

Tandem Cross-Metathesis/Hydrogenation Route to Lactones... 

Scheme 2.66 Tandem cross-metathesis/hydrogenation route to lactones [124].

Ru-catalyzed cross-metathesis, hydrogenation, and subsequent ring closure has been successfully combined into a one-pot tandem process for lactone synthesis. Importantly, compatibility between the catalytic systems is crucial to success. By employing the second generation Grubbs-Hoveyda catalyst in addition to Pt02, y- 6-lactones... 

---