Lactate dehydrogenase Cori cycle

Lactate is released by red blood cells and other cells that lack mitochondria or have low oxygen concentrations. In the Cori cycle, lactate is released by skeletal muscle during exercise (Figure 8.8). After lactate is transferred to the liver, it is reconverted to pyruvate by lactate dehydrogenase and then to glucose by gluconeogenesis. 

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