Lactarius necator Necatorone, Toadstool

The only natural product based on this ring system is necatorone 193. This alkaloid was isolated from a toadstool, Lactarius necator (84TL3575). This fungal metabolite showed a considerable mutagenic activity in the Ames test. A synthesis of necatorone 193 involving oxidative cyclization has been reported (Scheme 33) (85TL5975). 

Fugmann, B., B. Steffan, and W. Steglich Necatorone, an Alkaloidal Pigment from the Gilled Toadstool Lactarius necator (Agaricales). Tetrahedron Letters, 25, 3575 (1984). 

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