Lactame pharmacaphore

Scheme 48 Synthesis of a lactame pharmacaphore (Bristol-Meyers Squibb)...

After this success, Ir catalysts were employed more often, and it was shown that besides imines, C=0 as well as C=C btmds could be hydrogenated with good success. The hydrogenation depicted in Scheme 47 was developed by Lonza [38] for an intermediate of dextromethorphan and carried out on >100-kg scale. Important success factors were the ligand fine tuning and the use of a biphasic system. Chemoselectivity is high but catalyst productivity rather low for an economical technical application. Bristol-Meyers Squibb [111] achieved the first case of Ir diphosphine-catalyzed hydrogenation of a C=C bond to prepare a lactam pharmacaphore on a 20-kg scale (Scheme 48). DSM [112] in collaboration with Solvias developed a new route for biotin, based on the unprecedented reduction of... 

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See also in sourсe #XX -- [ ]

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