Laboratory methods for discerning

LABORATORY METHODS FOR DISCERNING INTRINSIC KINETICS OF MULTIPHASE REACTIONS... 

Automatization of all stages of the analytical process is a trend that can be discerned in the development of modern analytical methods for chemical manufacture, to various extents depending on reliability and cost-benefit considerations. Among the elements of reliability one counts conformity of the accuracy and precision of the method to the specifications of the manufacturing process, stability of the analytical system and closeness to real-time analysis. The latter is a requirement for feedback into automatic process-control systems. Since the investment in equipment for automatic online analysis may be high, this is frequently replaced by monitoring a property that is easy and inexpensive to measure and correlating that property with the analyte of interest. Such compromise is usually accompanied by a collection of samples that are sent to the analytical laboratory for determination, possibly at a lower cost. 

This relationship is widely used to predict a reasonable relative standard deviation for a given analyte concentration within a laboratory. AOAC (2003a) guidelines for single-laboratory validation of chemical methods also provide guidelines for acceptable recovery values, as shown in Table 4. Thus, armed with these guidelines it is possible to discern whether the experimental recovery rate, as well as the prcci.sioii of the method, is within acceptable boundaries. 

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