Labetalol dosage

Compounds that exhibit roughly the same affinity to and j32 rsceptors independent of dosage such as nadolol, propranolol, pindolol, timolol, and labetalol (combined a- and j3-adrenoblocker) are classified as nonselective blockers. Drugs which in therapeutic doses have higher affinity to -receptors than to j32-receptors such as acebutol, atenolol, metoprolol, and esmolol, are called selective or cardioselective j3-adrenoblockers. 

Withdrawal Hypersensitivity to catecholamines has been seen in patients withdrawn from -blockers. When discontinuing chronic labetalol, particularly in ischemic heart disease, gradually reduce dosage over 1 to 2 weeks and carefully monitor. Nonallergic bronchospasm (eg, chronic bronchitis, emphysema) Pat ents with bronchospastic disease should, in general, not receive -blockers. 

Drugs that may require dosage reduction with smoking cessation acetaminophen, caffeine, imipramine, oxazepam, penfazocine, propranolol, fheophylline, insulin, prazocin, labetalol... 

Carvedilol, like labetalol, is administered as a racemic mixture. The S(-) isomer is a nonselective B-adrenoceptor blocker, but both S(-) and R(+) isomers have approximately equal E-blocking potency. The isomers are stereoselectively metabolized in the liver, which means that their elimination half-lives may differ. The average half-life is 7-10 hours. The usual starting dosage of carvedilol for ordinary hypertension is 6.25 mg twice daily. Carvedilol reduces mortality in patients with heart failure and is therefore particularly... 

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