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L-Methylisatin-3-thiosemicarbazon

Methisazone 6.19) (l-methylisatin-3-thiosemicarbazone, Marboran ) inhibits the multiplication of vaccinia virus in experimental animals. The antiviral action is extraordinarily high. Mice infected intracerebrally with 1000 mean lethal doses (LD50) of vaccinia (cowpox) virus required only 0.5 mg/kg for protection, and only 10 mg/kg was needed for protection against variola major... [Pg.226]

Thiosemicarbazones - l-Methylisatin-3-thiosemicarbazone (methisazone "Marboran") prevented but did not cure smallpox in man and had a favorable effect on eczema vaccinatum and vaccinia gangrenosa A wider range of activity was seen in tissue culture with adeno, polio, varicella... [Pg.119]

See other pages where L-Methylisatin-3-thiosemicarbazon is mentioned: [Pg.57]    [Pg.284]    [Pg.268]    [Pg.57]    [Pg.284]    [Pg.268]    [Pg.177]    [Pg.943]   
See also in sourсe #XX -- [ Pg.284 ]



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