L-Dopa prodrugs

Others have also tried to develop L-dopa prodrugs. L-Dopa carboxyl esters were studied by Cooper and colleagues [5,6] and were not long-lasting. Garzon... 

Also, positive outcome was achieved after i.p. administration of the liposomal formulation of an L-dopa prodrug derivative to rats [218], It was shown that the level of dopamine in rat striatum was 2.5-fold higher to what was obtained after i.p. administration of L-dopa or the free prodrug itself. 

Di Stefano, A., Carafa, M., Sozio, P, Pinnen, F., Braghiroli, D., Orlando, G., Cannazza, G., Ricciutelli, M., Marianecci, C., and Santucci, E. (2004), Evaluation of rat striatal L-dopa and DA concentration after intraperitoneal administration of L-dopa prodrugs in liposomal formulations, J. Controlled Release, 99,293-300. 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

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