L-Benzyl-3-phenyl-thiourea

The synthesis l-benzyl-3-phenyl-thiourea (36) requires the application of a recently described and commercialized isatoic resin (19).1 Benzyla-mine readily reacts with isothiocyanato-benzene to afford l-benzyl-3-phenyl-thiourea (36). However, excess benzylamine needs to be removed by adding resin (19), thus providing pure product (36) upon simple filtration of the amide resin formed as depicted in Fig. 15. 

---