Kreysigine and colchicine pathway

From L-tyrosine, and alternatively also from L-phenylalanine, kreysigine synthesis begins with dopamine (Figure 2.16). S-autumnaline is derived via a Mannichlike reaction. S-autumnaline is converted into floramultine by the oxidative coupling. Subsequently, the kreysigine is synthesized through the activities of SAMe. From S-autumnaline, other alkaloids can also be derived. The destination of this pathway is colchicine (Figure 2.16). 

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