Konbu’acidin

The pyrrole ring is widely distributed in nature. It occurs in both terrestrial and marine plants and animals [1-3]. Examples of simple pyrroles include the Pseudomonas metabolite pyrrolnitrin, a recently discovered seabird hexahalogenated bipyrrole [4], and an ant trail pheromone. An illustration of the abundant complex natural pyrroles is konbu acidin A, a sponge metabolite that inhibits cyclin-dependent kinase 4. The enormous reactivity of pyrrole in electrophilic substitution reactions explains the occurrence of more than 100 naturally occurring halogenated pyrroles [2, 3]. 

Kalbretorine, 115 kistamycin, 99 komaroine, 102 konbu acidin A, 35 koumidine, 161 koumine, 161, 163 Kumada coupling, definition, 11... 

Kobayashi J, Suzuki M, Tsuda M (1997) Konbu acidin A, a New Bromopyrrole Alkaloid with cdk4 Inhibitory Activity from Hymeniacidon Sponge. Tetrahedron 53 15681... 

Inhibition of cyclin-dependent kinase 4 Konbu acidin (86) [124]... 

The complex fiised-hexaeyelic skeleton of konbu acidin A (70), containing two guanidine units is related to palau amine (46) and styloguanidines (55-57). This molecule was isolated from an Okinawan Hymeniacidon sp. and exhibited inhibitory aetivity against eyelin dependent kinase 4 (cdk4) [71]. 

Figure 10. Oroidin-like dimers konbu acidin A (70), axinellamines A-D (71-74), and massadine (75).

Kobayashi, J., Suzuki, M., Tsuda, M., (1997). Konbu acidin A, a new bromopyrrole alkaloid with edk4 inhibitory activity from Hymeniacidon sponge. Tetrahedron 53, 15681-15684. 

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