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Considerable site-directed mutagenesis work has been done with rat P450 1A2 (refs [206-208]) but relatively little with human P450 1A2. Some pharmacophore and homology - modeling work has been reported. [Pg.399]

The issue of coojjerativity will be discussed later under P450 3A4. Cooperativity has not been reported for human P450 1A2 but behavior of the rabbit ortholog has been interpreted in the context of multiple, overlapping binding sites . [Pg.399]

See other pages where Knowledge about Active Site is mentioned: [Pg.397]    [Pg.399]    [Pg.403]    [Pg.405]    [Pg.406]    [Pg.407]    [Pg.409]    [Pg.411]    [Pg.413]    [Pg.416]    [Pg.420]    [Pg.426]    [Pg.432]    [Pg.433]    [Pg.434]    [Pg.436]    [Pg.439]    [Pg.441]    [Pg.442]    [Pg.445]    [Pg.447]    [Pg.448]    [Pg.450]    [Pg.452]    [Pg.453]    [Pg.455]    [Pg.458]    [Pg.460]    [Pg.462]   


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