Knoevenagel/hetero-Diels-Alder multicomponent reactions

Radi M, Bernardo V, Bechi B, Castagnolo D, Pagano M, Botta M (2009) Microwave-assisted organocatalytic multicomponent Knoevenagel/hetero Diels-Alder reaction for the synthesis of 2,3-dihydropyran 2,3-c pyrazoles. Tetrahedron Lett 50 6572-6575... 

Another rapid protocol for the multicomponent microwave assisted organo-catalyst Knoevenagel/hetero Diels-Alder reaction (DKHDA) for the synthesis of substituted 2,3-dihydropyran [2,3-c] pyrazoles (xix) has been developed by Radi et al. [21]. 

G. Frapper, C. Bachmann, Y. Gu, R. Coval De Sousa, F. Jerome, Phys. Chem. Chem. Phys. 2011, 13, 628-636. Mechanisms of the Knoevenagel hetero Diels-Alder sequence in multicomponent reactions to dihydropyrans experimental and theoretical investigations into the role of water. 

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