Kirkpatrickia varialosa

Perry, N. B., Ettouati, L., litaudon, M., Blunt, J. W, Munro, M. H. G. Alkaloids from the antarctic sponge Kirkpatrickia varialosa. Part 1 variolin B, a new antitumour and antiviral compound. Tetrahedron 1994, 50, 3987-3992. 

Investigation of animals from the marine enviroiunent has thrown up an intriguing variety of poly-heterocyclic products (sometimes called sea alkaloids) five representatives are variolin B (sponge, Kirkpatrickia varialosa), lamellarin B (mollusc, Lamellaria sp.), ascididemine (mnicate, Didemnum sp.), wakayin ° (ascidian, Clavelina sp.) and dendrodoine" (tunicate, Dendroda grossular), a rare natural example of a multi-heteroatom compound. 

Variolins A and B have a newheteropolycyclic system of pyridopyrrolopyrimidine. These antitumor (P388 cells) and antiviral (HSV-1) compounds were isolated from the Antarctic species Kirkpatrickia varialosa harvested in the McMurdo Sound (Perry et al, 1994a, 1994b ... 

Perry, N.B., Ettouati, L Litaudon, M., Blunt, J.W., and Munro, M.H.G. (1994b) Alkaloids from the Antarctic sponge Kirkpatrickia varialosa. Part 2 variolin A and N(3 )-methyl tetrahydrovariohn B. Tetrahedron, 50, 3993 000. 

Kirkpatrickia varialosa. Part 1 variolin B, a new antitumor and antiviral compound. Tetrahedron, 50, 3987-3992. 

Meridianins display some structural similarities with variolins formerly isolated from the Antarctic sponge Kirkpatrickia varialosa (Chapter 19) and this led to the synthesis of meriolins, structurally hybrids of the two former groups (Bettayeb et al., 2007). 

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