Kinome targeting kinase family

Figure 5. An example of intra-family target hopping within kinases. According to SiteSorter, Braf kinase, the primary target for the clinical compound BAY 43-9006, is one of the 10 most similar kinases to c-Kit, which has also been shown to bind BAY 43-9006 with sub-micromolar affinity (60% of the binding site residues are consen/ed and colored blue non-consen/ed positions are colored yellow). This cross-reactivity cannot be predicted based on the sequence similarity of the Braf and c-Kit kinase domains, since approximately one-sixth of the human kinome is more sequence similar to Braf than c-KiL...

The second section focuses on target families such as kinases (R. Buijsman), ion channel modulators (K.-H. Baringhaus and G. Hessler), and phosphodiesterases (M. Hendrix and C. Kallus). In addition, the contribution of molecular informatics for chemogenomics (E. Jacoby et al.), chemical kinomics (B. Klebl), as well as proteochemometrics (J. Wikberg et al.) are discussed. 

---