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Kinetic Resolution of Allylic Esters

Asymmetric Synthesis of Allylic Sulfones and Allylic Sulfides and Kinetic Resolution of Allylic Esters... [Pg.216]

Kinetic resolutions of allylic esters have also been conducted. As noted in Chapter 14, in most cases, catalysts that are selective for kinetic resolution of substrates containing one type of functional group are also selective for reactions of meso substrates and vice versa.The enantioselective reaction of one acetate of a meso substrate involves similar stereochemical recognition to reaction of two enantiomers of a racemic mixture of allylic esters. In one illustrative example, an allylic acetate underwent reaction with a pivalate nucleophile to form the allylic pivalate product, which is less reactive than the starting compound (Equation 20.54). Reaction of one enantiomer of the racemic allylic acetate occurs preferentially, and the pivalate product is formed enantioselec-tively. The product of the resolution in Equation 20.54 was carried forward to form (+)-cyclophellitol. [Pg.995]




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Allylation esters

Esters allyl

Esters allylic

Esters kinetic resolution

Kinetic Resolutions of Esters

Kinetics esters

Of allyl ester

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