Kinetic control, in enolate formation

Under conditions for thermodynamic control, the major regioisomer formed is usually the enolate Carrying most substituents at the double bond. This can be attributed to the fact that the stability of C-C double bonds increases with increasing substitution6. Conditions for kinetic control in enolate formation usually favor formation of the enolate with the least substituents at the double bond. The rational for this is based on steric reasons, i.e., the less hindered proton is abstracted more rapidly than the hindered proton, giving the less substituted enolate. 

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See also in sourсe #XX -- [ , , ]

See also in sourсe #XX -- [ , , ]

See also in sourсe #XX -- [ , , , ]

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