Kinase inhibitors targeting with small molecule

Fig. 1 Interaction network and domain structure of B-Raf. (a) Interaction network from the STRING database (http //string-db.org) for human proto-oncogene B-Raf. The lines indicate interactions between the proteins, with thickness of the lines reflecting confidence of the displayed interaction, (b) Domain structure of B-Raf and structures of individual domains, illustrating the different functional units that could be targeted by small molecule inhibitors B-Raf RBD in complex with Ras (PDB code 3kud), diacylglycerol binding Cl domain (lfaq) and the kinase domain in complex with active site inhibitor Sorafenib (luwh)...

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