Kimel-Cope reaction

These flaws were pointed out by Kimel and Cope in 1943 [4]. They observed that acetoacetates, derived from the reaction of allylic alcohols and diketene, and the benzoylacetates of several j8,y-unsaturated alcohols reacted at elevated temperatures to give y,d-unsaturated ketones and CO2 (Table 8.1). 

Although Carroll identified the production of cinnamyl acetoacetate (188), the detailed mechanistic rationale was later provided by W. Kimel and Arthur C. Cope in 1943. The proposal invoked a pathway similar to the Claisen rearrangement. In 1968, Hill and Synerholm proved this hypothesis to be correct and studied the stereospecificity of the reaction. ... 

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